MYO6 and amyotrophic lateral sclerosis: Moreover, implication of OPTN in lysosome trafficking during autophagy in association with myosin VI has been reported, since ALS-mutant expression as well as knockdown of OPTN lead to blockage of lysosome-autophagosome fusion, hence accumulating autophagosomes in neuronal cells (Sundaramoorthy et al., 2015).