Importantly, activation of AMPK induces some of the ALS/FTD proteins to mislocalize or change its functional status, as observed for TDP-43 and TBK1 (Zhao et al., 2018; Liu et al., 2021), suggesting that AMPK activation is not a mere epiphenomenon but establishes a bidirectional crosstalk with ALS/FTD pathology. Here, TARDBP is linked to amyotrophic lateral sclerosis.