Mutations in LRRK2, such as G2019S (kinase domain) or ROC/COR domain (R1441C, R1441H and R1441G), enhance the protein’s kinase activity, and lead to impaired vesicular trafficking, lysosomal activity and mitochondrial function in PD brains (Ryan et al., 2015). This evidence concerns the gene LRRK2 and Parkinson disease.