And, specially, it has been seen that loss or chemical inhibition of TBK1, as well as expression of TBK1E696K, OPTINW478G and OPTINQ398X, which are ALS-linked mutations, impair mitophagy, thereby accumulation of damaged mitochondria occurs (Moore and Holzbaur, 2016). The gene discussed is TBK1; the disease is amyotrophic lateral sclerosis.