AD is characterized by the deposition of amyloid β protein (Aβ) in the form of extracellular amyloid plaques and by the presence of intracellular Neurofibrilary tangles (NFT) formed by hyperphosporylated Tau protein aggregates (TAU) (De Strooper and Karran, 2016). The gene discussed is MAPT; the disease is Alzheimer disease.