TARDBP and amyotrophic lateral sclerosis: ALS is often related to another neurodegenerative disorder with non-motor symptoms, the frontotemporal lobar dementia (FTD) (Lau et al., 2018), as they both share common clinical and pathological phenotypes—most notably, the existence of TDP-43 positive aggregates -, and even genetic causality (Robberecht and Philips, 2013; Pang and Hu, 2021); thus, they have been suggested to be part of the same spectrum of disease (Neumann et al., 2006).