LRRK2 and Parkinson disease: In addition to effects on macroautophagy, LRRK2 mutations were also reported to affect CMA (Orenstein et al., 2013) and mitophagy (Hsieh et al., 2016; Korecka et al., 2019), so most of the clearance routes have been shown to be altered in LRRK2-PD.