The former include, altered mitochondrial bioenergetics, impaired protein recycling (Al-Bari and Xu, 2020), where the master regulators mTOR and AMPK are crucial nutrient sensors (Hardie et al., 2012; Tan and Miyamoto, 2016), whereas protein aggregation and neuroinflammation are prominent non-cell-autonomous contributors to PD pathology, and it is believed to pathogenesis (Poewe et al., 2017). Here, MTOR is linked to Parkinson disease.