MAPT and Alzheimer disease: Moreover, genes that regulate autophagy, such as the phosphatidylinositol-binding clathrin assembly protein (PICALM), are correlated with the accumulation of tau in zebrafish and Drosophila models (Moreau et al., 2014) and have emerged as genetic risk factors for AD (Lee et al., 2011; Ortega-Rojas et al., 2016; Santos-Rebouças et al., 2017).