Given that tumor-associated macrophages (TAMs) can mediate cancer metastasis, chemotherapeutic resistance, and immune evasion through secreting CD24, CXCL8, CCL2, and other cytokines (Petty and Yang 2017), SLC1A5 is probably involved in the formation of the immune-tolerant microenvironment. This evidence concerns the gene CXCL8 and cancer.