However, due to the intratumor heterogeneity of HCC (23), the malignant transformation of liver cannot be fully explained by alternations in one or several particular signaling molecules (e.g., KRAS, BRAF, MEK, and ERK) and/or oncogenic pathways (e.g., AKT/mTOR, MAPK, and Wnt/β-catenin). This evidence concerns the gene MAP2K7 and hepatocellular carcinoma.