An immune checkpoint correlation analysis demonstrated that GSDME was closely associated with immune checkpoints TNFSF9, TNFSF15, TNFSF18, TNFSF4, TNFRSF25, TNFRSF4, TNFRSF8, LGALS9, NRP1, CD276, CD40, and CD200 in gastric cancer. This evidence concerns the gene TNFRSF25 and gastric cancer.