An immune checkpoint correlation analysis demonstrated that GSDME was closely associated with immune checkpoints TNFSF9, TNFSF15, TNFSF18, TNFSF4, TNFRSF25, TNFRSF4, TNFRSF8, LGALS9, NRP1, CD276, CD40, and CD200 in gastric cancer. Here, NRP1 is linked to gastric cancer.