Although GSDME has been less studied in gastric cancer, one study has shown that GSDME converts chemotherapy-induced caspase-3-dependent apoptosis to cellular scorching in gastric cancer cells (19).Our in vitro experiments also show that changes in GSDME expression may affect the biological behavior of gastric cancer cells, which may provide new ideas for the treatment of gastric cancer. This evidence concerns the gene CASP3 and gastric cancer.