An immune checkpoint correlation analysis demonstrated that GSDME was closely associated with immune checkpoints TNFSF9, TNFSF15, TNFSF18, TNFSF4, TNFRSF25, TNFRSF4, TNFRSF8, LGALS9, NRP1, CD276, CD40, and CD200 in gastric cancer. The gene discussed is TNFRSF4; the disease is gastric cancer.