The analysis revealed that the high expression of GSDME in gastric cancer was found in ECM_RECEPTOR_INTERACTION, HYPERTROPHIC_CARDIOMYOPATHY_ HCM, DILATED_CARDIOMYOPATHY, GLYCOSAMINOGLYCAN_ BIOSYNTHESIS_CHONDROITIN_SULFATE, and FOCAL_ADHESION, which have important roles. Here, GSDME is linked to gastric cancer.