Similarly, ginsenoside Rg3 treatment downregulates hypermethylated tRNA methyltransferase 1-like (TRMT1L), proteasome 26S subunit, ATPase 6 (PSMC6), and NADPH oxidase 4 (NOX4), while upregulating hypomethylated ST3 beta-galactoside alpha-2, 3-sialyltransferase 4 (ST3GAL4), RNLS, and KDM5A in breast cancer MCF-7 cells to block tumor growth (154). This evidence concerns the gene NOX4 and breast carcinoma.