In recent years, animal studies had found that uric acid played an important role in promoting glomerulosclerosis and interstitial cell fibrosis by impairing vascular endothelial function, stimulating proliferation of vascular smooth muscle cells, promoting inflammatory response and immune response, activating renin-angiotensin-aldosterone system, changing hemodynamics, and increasing systemic blood pressure and glomerular internal pressure [15–17]. This evidence concerns the gene REN and glomerulosclerosis.