IL13 and asthma: Eosinophils then release mediators, including cytokines (such as IL-13 and IL-5), chemokines, and cytotoxic granule proteins (such as eosinophil cationic protein (ECP) and eosinophil peroxides) [58, 59], causing airway damage and the remodeling of the airway, promoting the occurrence and development of asthma.