ARG1 and infection: The hub genes of CES and AMI (Figure 4(b)) were determined as ARG1 (Arginase-1), which is a key element of the urea cycle, and its role is to drive collagen synthesis and a bioenergy pathway that is essential for cell proliferation; CLEC4D (C-type lectin domain family 4 member D) acts as an endocytic receptor, which participates in the uptake of antigen at the site of infection or eliminates the antigen and presents it to T cells.