This result agrees with Kim et al. that revealed that Fimasartan significantly increased the antioxidant enzyme in unilateral ureteral obstruction in mice by up regulating expression of the mRNA of NQO1 and HO-1, the protein expression of those genes, as well as of CuSOD, MnSOD, and catalase [50]. The gene discussed is NQO1; the disease is Ureteral obstruction.