TNF and rheumatoid arthritis: Its mechanism of action works mainly through its active ingredients, such as quercetin, kaempferol, licochalcone A, and isorhamnetin, which act on key target genes such as CXCL8, PTGS2, VEGFA, and STAT3, thereby regulating the IL-17 signaling pathway, the TNF signaling pathway, the rheumatoid arthritis signaling pathway, and other related signaling pathways.