CXCR4 and neoplasm: Also, significantly elevated levels of angiogenesis inducing factors like CCR2, CXCR4, CCL2, CCL5, CXCL2, CXCL10, CXCL14, VEGF, and VEGFR1 and a few other transcripts were detected in microglia as well as macrophages isolated from tumor-bearing animals (Figure 3) [133].