Also, neutralizing IGFBP1 by a specific antibody in the microglial secretome after the administration of glioma cell conditioned medium spicily decreased tube formation in HUVEC, implying that stimulation of MCSF which resulted in upregulation of IGFBP1 secretion by microglial cells was fundamental for angiogenesis [134]. The gene discussed is IGFBP1; the disease is central nervous system cancer.