CXCL10 and neoplasm: Studies revealed that siRNA blockade of STAT3 in glioma cells resulted in microglial stimulation as well as tumor growth blockade in murine models, with upsurges in IL-2, IL-4, IL-12, IL-15, and CXCL10 as well as upregulation of CD80 and CD86 on myeloid cells (Figure 4) [137, 138].