ITGAM and central nervous system cancer: Studies revealed that microglial and macrophage populations are characterized by CD11b+/CD45dim (microglia) and CD11b+/CD45high (macrophages) phenotypes and constitutes about 13-34% (microglia) as well as about 4.2-12% (macrophages) of the tumor cell mass in experimental gliomas [98, 99].