LEF1 and familial pancreatic carcinoma: For example, miR-300 targets LEF-1 to inhibit HCC cell proliferation and metastasis [25]; miR-300 targets CRL4B to inhibit the development of pancreatic cancer [23]; miR-300 targets twist to inhibit the transformation of epithelial cells to mesenchymal cells [26]; and miR-300 inhibits the metastasis of osteosarcoma cells by targeting PTTG1 [27].