Meanwhile, plenty of new drugs, such as luteolin (Luo et al., 2019), ginsenoside Rg1 (Chen et al., 2019a), and baicalein (Yang et al., 2019) were also found to play a neuroprotective role by targeting the PI3K-Akt signaling pathway after ischemic stroke. This evidence concerns the gene PIK3CA and ischemic stroke.