The highest T1D risk in Emiratis was conferred by DRB1*04:05∼DQB1*03:02, DRB1*04:02∼DQB1*03:02 and DRB1*03:01∼DQB1*02:01 haplotypes. The gene discussed is HLA-DRB1; the disease is type 1 diabetes mellitus.