HLA-DRB1 and type 1 diabetes mellitus: Individual DRB1 and DQB1 alleles, or allelic combinations were associated with the altered risk of T1D, and both susceptible and protective DRB1, DQA1, and DQB1 alleles were reportedly implicated with T1D pathogenesis (Noble et al., 1996; Erlich et al., 2008).