Higher frequencies of DRB1*03:01∼DQB1*02:01 [0.44 vs. 0.18, OR = 3.44 (2.33–5.10), Pc = 3.48 × 10−10], DRB1*04:02∼DQB1*03:02 [0.077 vs. 0.014, OR = 6.06 (2.03–24.37), Pc = 2.3 × 10−3], and DRB1*04:05∼DQB1*03:02 [0.06 vs. 0.01, OR = 6.24 (1.79–33.34), Pc = 0.011] haplotypes, and lower frequency of DRB1*16:02∼DQB1*05:02 haplotype [0.024 vs. 0.075, OR (95% CI) = 0.30 (0.11–0.74), Pc = 0.041] were seen in T1D patients compared to controls. Here, HLA-DRB1 is linked to type 1 diabetes mellitus.