Finally, a Dnmt2 null mutation in the C57BL/6 background abolished the sensitivity to HFD (21–33% butter), and the animals do not gain weight and do not exhibit Type 2 diabetes-like traits, but unlike B6/D2 the transmission of obesity and diabetes in the offspring is also well abolished. Here, TRDMT1 is linked to obesity due to melanocortin 4 receptor deficiency.