In the present study, we analyzed blood-based F2RL3 methylation levels in 180 CHD patients and 184 healthy subjects in the Chinese population and proposed F2RL3 methylation, especially methylation at CpG sites adjacent to cg03636183, as an independent biomarker for the detection of CHD controlling variant CHD-related risk factors. The gene discussed is F2RL3; the disease is coronary artery disorder.