F2RL3 and influenza: In addition, in mice anti-platelet therapy [including aspirin, P2Y12 blockage and antagonists of αIIbβ3 or protease-activated receptor 4 (PAR4)] reduces platelet aggregation, leukocyte recruitment and infiltration, viral reproduction and alveolar damage, ameliorating survival and underlining the contribution of platelets to influenza-mediated lung pathologies (137, 149, 150).