Celastrol, a pentacyclic triterpene from Tripterygium wilfordi root extract, exhibited neuroprotective properties in a MPTP-induced PD mouse model and AAV-mediated human α-synuclein overexpression in a PD model by inhibiting NLRP3 through the Nrf2 signaling pathway (135). The gene discussed is NLRP3; the disease is Parkinson disease.