A protein with comparable capacities in skewing T2 immunity and limiting type 1 and type 17 differentiation is the B lymphocyte-induced maturation protein-1 (PRDM1) (42), whereas PRDM1 expression in CRSwNP was restricted to TC1, 4, 5, and Treg; we found additional upregulation in the Th2 clusters TC2 and TC6 in AERD (Figure 6M and Table S6). Here, PRDM1 is linked to chronic rhinosinusitis with nasal polyps.