Expression of the carbohydrate metabolism-associated gene ALDH3A1 (Figure 4O), the antimicrobial protein clusterin (CLU) (Figure 4P), and calmodulin 2 (CALM2) (Figure 4Q), a calcium-binding protein involved in mediating ciliary beat responses in the human nasal epithelium (34), were also significantly reduced in cells from AERD as compared to CRSwNP patients. Here, CLU is linked to chronic rhinosinusitis with nasal polyps.