In patients suffering from AERD as compared to CRSwNP, the top upregulated differentially expressed genes (DEG) across all MC clusters included IL17RB (Figure 3C), VEGFA (Figure 3D), CSF1 (Figure 3E), the nuclear enriched abundant transcript NEAT1, which is thought to play a role in inflammasome activation (26), and the 15-hydroxyprostaglandin dehydrogenase HPGD (Figures 3F–H) (8). Here, HPGD is linked to chronic rhinosinusitis with nasal polyps.