Xenografts of the human HNSCC cell line FaDu cells demonstrated decreased tumor growth, reduced proliferation and reduced levels of MMP-9 and VEGF after CD147 was knocked down (145), and tumors generated with the mouse CD147-KD P388D1 cells resulted in smaller tumors, inhibited MMP-11 levels, and reduced ability to migrate to lymph nodes (146). This evidence concerns the gene BSG and head and neck squamous cell carcinoma.