Perivascular TAMs (identified as Tie2+VEGFA+MRC1+) promote angiogenesis and vascular permeability by enhancing VEGF secretion (68, 69), and assist in generating specialized temporal structures (called tumor microenvironment of metastasis-TMEM) that are based on direct cell-cell contacts with both tumor cells and endothelial cells. The gene discussed is MRC1; the disease is neoplasm.