Mice deficient for its only known ligand Ox40L (Ox40L-/- mice) show impaired adult worm expulsion, lower IL-4 production and parasite-specific IgE responses following a secondary H. polygyrus infection, highlighting Ox40-Ox40L interactions as key for host immunity to a challenge nematode infection (17). This evidence concerns the gene IGHE and Nematoda infectious disease.