Overall, our RNAseq analysis in H. polygyrus-cured mice revealed that, at 8 weeks following cure of a primary nematode infection, mice harbor both a circulating pool of central memory-type CD4+ cells in secondary lymph organs like the mLN, and CD4+ T cells with a tissue-resident, antigen-experienced Th2 phenotype. This evidence concerns the gene CD4 and Nematoda infectious disease.