Within neurons, the +1128T/C SNP also increases the secretion of NPY post-translationally (100, 106).These genetic associations of NPY, along with the clinical data that show elevated NPY in the plasma and affected skin of some vitiligo patients (63), implicate NPY as a contributing factor to vitiligo pathology and a potential target for therapeutic development in patients with these mutations. This evidence concerns the gene NPY and vitiligo.