AQP4 and acute disseminated encephalomyelitis: TDLs can also occur in patients with other atypical demyelinating syndromes, such as acute disseminated encephalomyelitis (ADEM), aquaporin 4 (AQ4) IgG seropositive or MOG- seropositive Neuromyelitis Optica Spectrum Disorder (NMOSD), as well as other neuroinflammatory disorders including neurosarcoidosis and Behçet's disease (8).