TDLs can also occur in patients with other atypical demyelinating syndromes, such as acute disseminated encephalomyelitis (ADEM), aquaporin 4 (AQ4) IgG seropositive or MOG- seropositive Neuromyelitis Optica Spectrum Disorder (NMOSD), as well as other neuroinflammatory disorders including neurosarcoidosis and Behçet's disease (8). This evidence concerns the gene AQP4 and neuromyelitis optica.