In this study, we demonstrated that the hyperphosphorylation and lateralization of Cx43 are involved in the prolonged QRS complex in EAM rats, and blockade of PKC not only prevents the hyperphosphorylation and lateralization of Cx43 but also ameliorates the prolongation of QRS complex (Figure 4), which indicates that Cx43 may serve as a drug target for pharmaceutical intervention of myocarditis-associated with QRS complex. This evidence concerns the gene GJA1 and myocarditis.