ABCB1 and gastric neoplasm: It was demonstrated that compound 78 (5, 10, and 20 μmol/L) alone or in combination with ADR could inhibit protein expression levels of ABCB1, and reversed MDR of gastric neoplasm to anticancer drugs by downregulating the Cox-2/PKC-α/ABCB1/mdr1 signaling pathway in human gastric cancer SGC7901/ADR Cells (Sun and Li, 2014).