Six new jatrophane-type diterpenoids and three known diterpenes were isolated from the whole undried plants of Euphorbia esula (Table 1), most of which were able to enhance the Rhodamine 123 (Rh123) accumulation in human ABCB1-transfected L5178Y mouse T-lymphoma cells, overexpressing ABCB1 (Vasas et al., 2011). This evidence concerns the gene ABCB1 and lymphoma.