As NLRP3, IL-1β, and IL-18 are regulated by NF-κB (Bauernfeind et al., 2009; Zhu and Kanneganti, 2017; Cornut et al., 2020), we tested the influence of CAN on the NF-κB pathway. The gene discussed is NLRP3; the disease is Crouzon syndrome-acanthosis nigricans syndrome.