Liu et al. discovered that ASPP2 induced the apoptosis of hepatoma cells by dissociating Beclin-1 from Bcl-2-Beclin-1 complex, maintaining the generation of ASPP2-Bcl-2 complex and triggering autophagic apoptosis (Liu et al., 2014). The gene discussed is TP53BP2; the disease is hepatocellular carcinoma.