B cell-deficient mice inhibit tumor growth through increased cytotoxic CD8 T cell and reduced regulatory T cell populations in several tumor models, such as EL4 thymoma, MC38 colon carcinoma, and EMT-6 breast carcinoma (Shah et al., 2005; Tadmor et al., 2011; Zhang et al., 2013). The gene discussed is CD8A; the disease is neoplasm.