MAPT and tauopathy: Moreover, UV exposure for 10 mins also increased PLA foci for PHF-tau (AT100; pThr212/ Ser214) and heterochomatin (Supplemental Fig. S4e, f).The induction of DSB with etoposide increased the toxic oligomeric tau stained with anti-T22 antibody in a dose-dependent manner, indicating that DSB-relevant perinuclear p-tau accumulation is linked to neurodegeneration in tauopathy (Fig. 4d and Supplemental Fig. 5).