Furthermore, there are reports which suggest that p-tau re-locates to the nuclear membrane, interacts with the NPC, and inhibits nucleus-cytosol transports in tau transgenic mice and AD brain39, thereby resulting in cytoplasmic aggregates, which comprise of phosphorylated tau and nuclear pore proteins in neurons with neurofibrillary tangles (NFTs)39. The gene discussed is MAPT; the disease is Alzheimer disease.