Given the propensity for loss of functional pancreatic acinar tissue secondary to ADM and atrophy on loss of either phosphatase, particularly in mice lacking DUSP5, it will be interesting to make use of the more recently developed “postnatal” models of pancreatic cancer [29] rather than the “prenatal” or developmental model used here as well as orthotopic transplantation of PDAC tumour cell lines. Here, DUSP5 is linked to neoplasm.