Approximately 90% of pancreatic cancers harbour activating mutations in KRAS and this murine model faithfully recapitulates the full spectrum of histological lesions that characterise the progression of human pancreatic carcinogenesis, giving rise to pancreatic ductal adenocarcinomas (PDAC) that display desmoplastic stroma and inflammatory responses closely resembling those observed in human patients [27]. Here, KRAS is linked to familial pancreatic carcinoma.