We therefore obtained a second conditional strain (Dusp5Mfl/fl), which expresses wild type levels of DUSP5 protein and is efficiently deleted by Cre recombinase in both MEF’s and mouse tissue (Fig. S4C, D) and repeated our pancreatic cancer experiments aging mice to 56 and 100-days. The gene discussed is DUSP5; the disease is familial pancreatic carcinoma.