ROR1 and B-cell chronic lymphocytic leukemia: Furthermore, we found that CLL cells at SC2 had higher expression of genes implicated in the non-canonical Wnt signaling, but not genes induced through activation of the canonical β-catenin/Wnt signaling pathway; we found changes in gene expression similar to those in SC2 versus SC12 in MEC1-ROR1 versus MEC1 cells, indicating that ROR1 alone was sufficient to induce such changes in gene expression for this cell line, which has constitutive high-level expression of Wnt5a.