After taking into account the confounding effects such as sex, age groups, and ethnicity, four signs and symptoms were found independently associated with the dominance of P.1, including coryza (MOR 4.378 [95% CI 3.08–6.22]; p < 0.001) and two neurological symptoms, ageusia (MOR 2.37 [95% CI 1.61–3.49]; p = 0.001) and headache (MOR 9.56 [95% CI 7.30–12.52]; p < 0.001). Here, OCA2 is linked to Headache.