Not surprisingly, CIN is one of the catalysts that induces acquired resistance to radio- and chemotherapy by continuously generating heterogeneous cell populations that eventually do not respond to treatment.170 We recently showed that the lncRNA CCAT2, which is highly overexpressed in colorectal cancer49 and myeloproliferative neoplasia, and can induce myeloproliferative neoplasia in vivo,171 is a component of the CIN pathway. Here, CCAT2 is linked to cervical squamous intraepithelial neoplasia.