Not surprisingly, high CCAT2 levels in CRC cell lines are associated with resistance to the two main chemotherapeutics used in gastrointestinal cancers, 5-flurouracil (5-FU) and oxaliplatin.50 By studying the role of mesenchymal stem cells (MSCs) in gastric cancer, He et al. proved that their role in chemoresistance is mediated by the lncRNA MACC1-AS1. This evidence concerns the gene CCAT2 and colorectal carcinoma.