As apparent in the oGTT at 6 weeks, and exacerbated after 16 weeks, HFV showed a strong delay in glucose clearance, as seen in the incremental AUC (iAUC) (Fig. 2C, D), with no difference between HF and HFV feeding in insulin secretion, suggesting peripheral insulin resistance (IR) in HFV mice (Fig. 2E, F). Here, INS is linked to hydrops fetalis.