APOE and atherosclerosis: In atherosclerotic mice, median heart signal at 120 min was 1.4 (IQR, 1.2–1.4) %ID/g, which was significantly higher compared to 0.7%ID/g in time-matched controls (IQR, 0.7–0.8, p = 0.0159, Fig. 2E and Supplementary Fig. S3A; Supplementary Tables S2 and S3, C57Bl/6 N = 5 and Apoe−/− N = 4), most likely due to atherosclerosis-driven chronic inflammation.