As shown in Fig. 2F, the expression of p53, TNFR1, FAS, BID (BH3 interacting domain), BAX (Bcl2-associated X protein), FADD (Fas-associated death domain) and DAXX (death domain associated protein), at the mRNA level was significantly increased in AHL mice. The gene discussed is BID; the disease is acute hemorrhagic leukoencephalitis.