All immune cell clusters were identified in both the tumor and juxtatumor samples, but the relative proportions of mmDC, pDC, B cells, Plasma cells, Neutrophils, and Mast cells were increased in the tumor samples whereas MMAC_PDL1 and MMAC_NLRP3 were increased in the juxtatumor sample (Supplementary Fig. 12B, Supplementary Table 9). The gene discussed is NLRP3; the disease is neoplasm.