In particular, we considered only arcs into the “CD8 T cells” node (i.e., a leaf node), only arcs that originate from the “Cancer” node (i.e., a root node), mostly arcs that originate from the “CCN4” node (with exception for the “Cancer” node), and only arcs into the “CD4 T cells” and “Neutrophils” nodes. Here, CD4 is linked to cancer.