CCN4 and neoplasm: In both the CD4+ and CD8+ T cell populations, the presence of tumor-conditioned media significantly inhibited the fraction of cells that divided at least once (Dil - CD4 p-value = 0.022, CD8 p-value = 0.018) and the probability that a cell will divide at least once (PF - CD4 p-value = 0.024, CD8 p-value = 0.013) while CCN4 protein exposure was not a statistically significant factor.