The percentage of CD45+ cells among total live cells exhibited a semi-log dependence on tumor size (Fig. 6A - B16F0: R2 = 0.607, F-test p-value = 7.27E-6; YUMM1.7: R2 = 0.830, F-test p-value = 1.48E-7), where CCN4 KO resulted in smaller tumors in both cell models with greater CD45+ cell infiltration. This evidence concerns the gene CCN4 and neoplasm.