To explore the interaction of ERRγ/GATA4 with the coactivator PGC-1α, IP was performed with epitope-tagged ERRγ (3xFLAG), PGC-1α (Myc/His), and GATA4 (HA) in AD-293 cells (Supplementary Fig. 7c). Here, PPARGC1A is linked to Alzheimer disease.