Target antigens could include: A) tumor associated cell surface antigens (PD-L1, CD20, CD19, MSLN (Mesothelin), Claudin18.2, and Her2), B) immune checkpoint proteins (PD-1, CD40, 41BB), and C) cytokines or receptors (CSF-2 receptor, VEGF). The gene discussed is CD274; the disease is neoplasm.