In addition, loss of HOTAIR in GBM cells suppresses HK2 expression and leads to the ensuing suppression of proliferative phenotypes and enhancement of sensitivity to TMZ in vitro and in vivo [17] Overall, these data demonstrate that serum-EV HOTAIR can be used as a novel prognostic and diagnostic biomarker for GBM. The gene discussed is HOTAIR; the disease is glioblastoma.