HOTAIR and glioblastoma: In spite of the aforementioned extensive investigations regarding TMZ resistance and several ones that have indicated the TMZ resistance-promoting role of HOTAIR [19], the present study stands out for exploring the clinically isolated EVs in both in vitro and in vivo models, wherein HOTAIR-loaded GBM-serum-EVs were reasonably elucidated to be a novel prognostic and diagnostic biomarker for GBM.