In a coculture of THP-1 macrophage-like cells overexpressing Siglec-15 with lung cancer cells overexpressing sTn synthase, M-CSF induced M2-like macrophages to express Siglec-15, which was not upregulated on M1-like macrophages, and produced TGF-β via the DAP12-Syk pathway, thereby promoting tumor metastasis[29]. This evidence concerns the gene TGFB1 and neoplasm.