Although BRD7 has been reported to act as a chaperone for nuclear transport of p85α and p85β30,31, our data suggest that BRD7 is not the major mediator of p85β nuclear translocation in PIK3CA helical domain mutant cancer cells, because knockout of BRD7 only had a marginal effect on nuclear p85β levels. The gene discussed is PIK3R2; the disease is cancer.