While the authors observed a linear relationship between the overall cancer-related mortality and serum OPG (RR of cancer-related mortality increased by 25% per 1 standard deviation increase in serum OPG, RR 63% higher in upper vs. lower tertile), only 7 out of 6279 cases were related to breast cancer [39]. The gene discussed is TNFRSF11B; the disease is breast cancer.