Conversely, in a recent study conducted by Kotsopoulos et al., the authors observed no substantial evidence of an association between plasma OPG and breast cancer risk among premenopausal women in a case-control analysis nested within the Nurses’ Health Study II; however, the authors observed a suggestive inverse trend and their analyses may have been underpowered (highest vs. lowest quartile OR = 0.78; 95% CI 0.46–1.33; ptrend = 0.30) [43]. This evidence concerns the gene TNFRSF11B and breast cancer.