HMOX1 and gastric cancer: In addition, the multivariate Cox data illustrated that overexpression of Nrf2 (P = 0.035, RR = 1.583, 95% CI 1.033-2.426) and HO-1 (P<0.001, RR = 2.156, 95% CI 1.428-3.257) were independent predictive factors for the survival of individuals with GC (Table 5).