IL7R and infection: Testing this further, we found that infection also downregulated the IL-7 receptor α subunit (CD127) from the cell surface (Figure 7C) and transcriptionally (fold change = 0.693, adjusted p = 5.89 × 10−8; Data S1) (Park et al., 2004), collectively indicative of HIV-1 inducing enhanced JAK-STAT signaling even in the absence of IL-7.