To gain greater insight into the native effects of HIV-1 and Vpr on T cells, gene set enrichment analysis (GSEA) (Figure 5G) and ingenuity pathway analysis (IPA) (Figures 5H and 5I) were performed on data from infected cells in the absence of IL-7 treatment, since IL-7 was not required for productive infection of resting memory T cells (Figure 1). The gene discussed is IL7; the disease is infection.