Theintracellular multiprotein complex, inflammasome, also plays an important rolein activating the enzymes of the cysteine-aspartic proteases family (caspases).Therefore, the role of the NLR family pyrin domain containing 3 (NLRP3)inflammasome in AMD pathogenesis has been extensively investigated. This evidence concerns the gene NLRP3 and age-related macular degeneration.