Astudy suggested that the G→C transversion at the 19th position in theHMOX1 gene (the 19G>C-HMOX1polymorphism, rs2071747) and - 42 + 1444 position in the HMOX2 gene (the - 42+1444A>G-HMOX2 polymorphism, rs2270363) may beassociated with individual susceptibility to AMD(98). The gene discussed is HMOX2; the disease is age-related macular degeneration.