In view ofthose findings, they hypothesized that the worse BCVA in the cases of SRD may havebeen associated with the photoreceptor cell damage caused by the macular detachmentand functional impairment secondary to ischemia amid the high levels of VEGF invitreous fluid(16). The gene discussed is VEGFA; the disease is dopa-responsive dystonia due to sepiapterin reductase deficiency.