Previous study reported thatdexmedetomidine treatment alleviated myocardial infarction-mediated AKI throughrestricting endoplasmic reticulum stress16.Another study showed that renal I/R-impaired injury was prevented by fibroblastgrowth factor2 treatment dependent on the modulation of endoplasmic reticulum stressby activation of PI3K/AKTand MEK-ERK1/2 signals17. The gene discussed is MAPK3; the disease is acute kidney injury.