Some physicians kept patients on diuretics only, possibly without knowing about the potential benefits of angiotensin-converting enzyme inhibitors and beta-blockers.(26) Besides being indicated only for the advanced stages of heart failure and management of clinical decompensation events, loop diuretics in older adults are associated with hypotension, urinary incontinence, hyponatremia, and kidney injury.(22,27). The gene discussed is ACE; the disease is heart failure.